Source: http://www.69cyberline.com/2011/08/the-truth-behind-electronic-cigarette-reviews/
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Wednesday, August 31, 2011
The Truth Behind Electronic Cigarette Reviews
[unable to retrieve full-text content]Which are the best electronic cigarettes on the market? With so much choice out there and the claims made in the reviews, are they true, or just the companies themselves writing the reviews in order that you pick their product ...
Small-Business Owners: What Obama Needs to Do for Us (ContributorNetwork)
President Barack Obama will address the nation after Labor Day on jobs and the economy. Yahoo! Contributors asked Americans what they'd like to hear from him. Below are some responses.
[Your Voice: What worries do you have about politics, jobs and the economy? Sign up to contribute.]
In early September, President Barack Obama will reveal his plan to create jobs as many small-business owners continue to be concerned about the future of their companies. Here is what some of them said they hope to hear from the president in his speech.
"I'm not sure anyone can do anything right now except wait out a bad economy. If I could get Obama to do one thing it would be to help small-business owners with getting better loans. It takes money to make money, and it's really hard for a business owner with not-so-great personal credit to make a name for themselves, credit-wise, to make expansions so they can then earn a better credit name for themselves. To be fair, I don't think anyone, not just Obama, really could of done too much with how bad it was when he went into office." -- Jessica Merrifield, owner and operator of The Real Witches (a locally well known and highly reputable psychic reading and spell casting company) in Carson City, Nev.
"The most important thing he can do would be to stop subsidizing Big Agriculture and give those subsidies to small-scale farmers. We are just trying to feed our local communities and to be able to make a living doing it. By allowing Monsanto to continue to poison our food we are hurting everyone in the process." -- Linda Harriman, owner and operator of Sunny Sally Farms in Oakdale, Calif.
"Ending the red tape that it takes to obtain organic certification for a small farm is one of my biggest concerns. Right now, the process serves large-scale operations much more than small ones. Before I undertook the effort to create a small, profitable farm for our community, I had no idea how much red tape and brick walls I would hit along the way." -- Paul Houghton, owner of The Laughing Lady Farm in Eugene, Ore.
"Give tax breaks to the small businesses, and not the wealthy corporations. Small businesses are the back bone of our economy and our communities. Enable us to hire more people and get our local citizens back to work one." -- Robert Moore, owner of Mushrooms and Moore in Carpenterville, Ore.
"Provide more tax incentives for going green. There has been some effort in that already, but I think that is one of the biggest ways he can help. We need to build our economy back up with projects that are sustainable in the long term. Help people to build homes and buildings that are more environmentally friendly and not only will we have more jobs, but a better future. We need more jobs that will not be sent overseas. They need to be here at home, where American citizens can get back to work and have hope for the future again." -- Leah Robinns, owner and manager of a small natural clothing store in Santa Cruz, Calif.
"I spend so much time doing paperwork in order to comply with all of the government regulations in my small business that it takes away from the time I could be marketing and promoting or doing other much more productive things. Helping small businesses by reducing the red tape and regulations would be a big help." -- Michele Harvey, owner of Harvey's Helping Hands in Cleveland, Tenn.
"My biggest issue and concern is taxes. Not just the amount of money that small businesses have to pay, although that is certainly a factor. It is the complexity of the tax code and the time and effort it takes just to try and figure it out and comply. Simplifying the tax code as well as keeping taxes on small businesses to a minimum is key." -- Joy Anderson, co-owner of Anderson and Miller, a small financial consulting business, in Fresno, Calif.
"Make money available to help people create small businesses and put more people in their own communities back to work. It is almost impossible to get a loan and start up a business now. With so many people unable to find work, if they were able to start their own profitable business it would not only take one more person out of the unemployment line, it would have a domino effect by creating more jobs as the business grows." -- Erin England, owner of England's Resumes and More in Longmont, Colo.
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Simple Online Business Ideas
There are many different things you can do which will increase the success of your online business. The goal of this article will be to help you find a way to improve your business as it sits right now. My personal expertise is search engine optimization so the majority of this article will be making sure you have a corelation between what you sale and what you are attempting to rank your website or blog for. Online business has three main properties to it the first being creation which is when you set up your website or blog, next is internet marketing and this consists of everything from social networking to ranking your presence at the top of the major search engines, finally there is monetization which is when you earn money from the traffic you get to your website. Some of the common monetization methods include ppc publising, affiliate marketing, and product creation/selling.
The first thing when creating an online business or running an online business is understanding what the web traffic coming to your website wants. To get this understanding you much keep track of where and how the traffic is coming to your website. This is why online business owners install a website counter. The two top counters which will help evaluate the incoming traffic sources include statcounter.com and Google Analytics which you will find in your Google Account Settings. Both of these two will allow you to tell exactly what is bringing in the traffic. One of the most important incoming sources to check is keywords. These websites will let you know what keywords searching for to find your website. Make sure you check to see what position you are at for these keywords and if you are not number one start building links to reach the top.
The final topic I would like to discuss is testing and utilizing monetization techniques when trying to become a successful online business professional. Many think you throw Google Adsense up and begin making thousands, but this is rarely the case. A much more usual circumstance is barely making anything with adsense and having to test many different monetization techniques. One of the monetization techniques which I use is the affiliate programs on paid surveys websites. These are extremely easy to market because people sign up and make money for free. Some other websites that are worth testing out if you are trying to make money from your traffic are amazon and clickbank. These two websites have many different affiliate products in every niche imaginable.
You must remember that if you decide to open and run an online business it is important to be ready for years of work. No one makes it online overnight it is a long and tedious process. The main thing you should worry about in the first year is learning everything you can about online business especially internet marketing.
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Source: http://foryouarticles.com/index.php/simple-online-business-ideas/
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Tuesday, August 30, 2011
Ask the Commenters Roundup [Hive Mind]
0- I borrowed my roommate's detergent. Is there anything I can do besides avoiding human contact at my desk to mitigate the god-awful detergent from hell odor?
- Can anyone recommend any good budgeting software? I want to sort out my financials and I haven't got a clue where to begin!
- I'm hoping to learn the magical ways of linux. Where do i start? What do i need to know?
- I just bought a new laptop (win 7) last night, so it's on the way to my house. I was wondering what you all would recommend I do once I get it, as far as security, clean up, etc?
- I need a new wireless router. It needs to be some sort of bad ass router for my new apartment. DUAL BANDS, retarded DATA throughput, range so far the radio waves give kids cancer at 300 yards. That kind of stuff. I personally have been interested in dd-wrt for a while now. What should I get lifehacker?
- Can anyone give some tips or helpful links on job searching and resume writing for a guy trying to get his first job?
- We just got a new Netgear N Router, and I want to use the old Netgear G Router to either use as repeater for the upstairs, or as a bridge somehow for the XBMC box in my room. However, I don't want to have to wire everything from the basement. It's just not worth the hassle. Any advice?
- I'm looking for recommendations on the best cloud backup services for macs.
- Tomorrow's my 21st birthday, what should I do? (Happy Birthday Phaelin!)
- Has anyone had any experience with the Livescribe pens, specifically the Echo?
Source: http://feeds.gawker.com/~r/lifehacker/full/~3/j6t5rUnBsFo/ask-the-commenters-roundup
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bad credit student loans ? Bad Credit Student ... - guitar lessons online
Getting a credit service is not difficult for those with good credit image. But those having poor credit history find it really very difficult to arrange cash. This problem gets worse in the case of students. In most of the cases, they do not have any source of income. This makes them incapable to apply for any loan. But now they need not worry. We have found out the solution to all their worry. Bad credit student loans will surely help them in getting out of financial crises.
Bad credit student loans are specially designed loans for those students who are in the need of money but could not arrange it in time. They find it really very difficult to borrow money. But now they can easily get loan under this scheme. Even persons with poor credit history may apply for such advances. They need not worry about their credit scores. Lenders are not at all interested in these scores.
These advances are generally of secured nature. It means that students need to keep any of their assets with the lender to take the loan. The amount of such loans may vary as per the value of the collateral. To make the complete situation easier, even parents of the students may apply for such loans on their behalf. They may also act as a guarantor in the loan process.
You may also apply for such loans via internet too. It will surely make the complete process very efficient and fast. You may also compare the rates and other charges of different lenders and accordingly select the best out of it.
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These advances are generally of secured nature. It means that students need to keep any of their assets with the lender to take the loan. The amount of such loans may vary as per the value of the collateral. To make the complete situation easier, even parents of the students may apply for such loans on their behalf. They may also act as a guarantor in the loan process.
You may also apply for such loans via internet too. It will surely make the complete process very efficient and fast. You may also compare the rates and other charges of different lenders and accordingly select the best out of it.
johnsimen -
About the Author:
John Simen is habitual of writing articles on the loans. He gives the right suggestions to the loan seekers. To learn out more about student loans for bad credit, http://www.studentloansforbadcredit.net/
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Cassini closes in on Saturn's tumbling moon Hyperion
ScienceDaily (Aug. 27, 2011) ? NASA's Cassini spacecraft captured new views of Saturn's oddly shaped moon Hyperion during its encounter with a cratered body on Thursday, Aug. 25. Raw images were acquired as the spacecraft flew past the moon at a distance of about 15,500 miles (25,000 kilometers), making this the second closest encounter.
Hyperion is a small moon -- just 168 miles (270 kilometers) across. It has an irregular shape and surface appearance, and it rotates chaotically as it tumbles along in orbit. This odd rotation prevented scientists from predicting exactly what terrain the spacecraft's cameras would image during this flyby.
However, this flyby's closeness has likely allowed Cassini's cameras to map new territory. At the very least, it will help scientists improve color measurements of the moon. It will also help them determine how the moon's brightness changes as lighting and viewing conditions change, which can provide insight into the texture of the surface. The color measurements provide additional information about different materials on the moon's deeply pitted surface.
The latest raw images of Hyperion are online at: http://saturn.jpl.nasa.gov/photos/raw/ .
Cassini's closest encounter with Hyperion was on September 26, 2005, when the spacecraft flew approximately 310 miles (500 kilometers) above the moon's surface. Cassini's next flyby of Hyperion will be on Sept. 16, 2011, when it passes the tumbling moon at a distance of about 36,000 miles (58,000 kilometers).
The Cassini-Huygens mission is a cooperative project of NASA, the European Space Agency and the Italian Space Agency. The Jet Propulsion Laboratory, a division of the California Institute of Technology in Pasadena, manages the mission for NASA's Science Mission Directorate, Washington. The Cassini orbiter and its two onboard cameras were designed, developed and assembled at JPL. The imaging operations center is based at the Space Science Institute in Boulder, Colo.
For more information about the Cassini-Huygens mission, visit http://www.nasa.gov/cassini and http://saturn.jpl.nasa.gov .
Email or share this story:
Story Source:
The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by NASA/Jet Propulsion Laboratory.
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/fQZiWf8_l3g/110827191804.htm
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Entry Level Sales and Marketing ? Management Training (Tigard ...
: Archetype, inc. is hiring for entry level sales and marketing positions. This job involves face to face sales of services to new business prospects. Archetype, inc. is hiring for entry level sales and marketing positions. as an outsourced marketing firm for the Fortune 500 community, we guarantee results and deliver them with efficiency and integrity. our clients hire us as a satellite marketing and sales office without the headaches, expenses, and overhead that come with doing it themselves. our company holds itself to the highest standards, working only with industry leaders who share our values. The Personal approach: our method is simple: we apply a customer friendly, face-to-face approach to our promotions and sales strategies. by directly meeting with customers we can dramatically increase our clients sales without dramatically increasing their budget. our technique is proven to be the most effective way to penetrate a target market and acquire new, profitable customers. Responsibilities in this program include: Sales Training Sales / Marketing Human Resources Marketing Strategies and Sales Techniques Oversee Campaign Development Manage Customer Service, Administration, and Sales Personnel This is an entry-level position. having a degree in communications, business administration, management, advertising, marketing, public relations, political science, psychology, sociology, and sports management have proven to work best with our corporate culture. Athletic backgrounds are welcomed because of the competitive nature and social energy they can bring to our environment. This is not a telemarketing position. all positions are full time and will be filled immediately. for immediate consideration, submit your resume from our website. PLEASE VISIT OUR WEBSITE TO APPLY ONLINE ON THE ?CAREERS? TAB Thank you and good luck in your search! Archetype, inc is an Equal Opportunity Employer. we do not discriminate based on race, sex, creed, or age. Pay based upon performance. People from all backgrounds seeking full time opportunities or full time internships in the following areas are encouraged to inquire about our program: sales, customer service, manager, marketing, administrative, human resources, entry level, purchasing, director, retail, health care, education, project manger, teacher, real estate, insurance, telecommunications, banking, restaurant, advertising, supervisor, public relations, hotel, communications, social services, business and sales psychology, collections, pharmaceutical sales, buyer, recruiter, hospitality. Desired degrees and courses include but are not limited to: pr, advertising, public relations, sales, management, marketing, professional selling, business administration, human resources, recruiting, sports management, restaurant management, and hospitality. Location: Tigard Compensation: 30-50k Principals only. Recruiters, please don?t contact this job poster. please, no phone calls about this job! please do not contact job poster about other services, products or commercial interests.
Click link below to read full and original article
View post: Entry Level Sales and Marketing ? Management Training (Tigard)
Entry Level Sales and Marketing ? Management Training (Tigard)
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Source: http://www.business4noobs.com/entry-level-sales-and-marketing-management-training-tigard/
Monday, August 29, 2011
Judge blocks Facebook limits for teachers
JEFFERSON CITY, Mo.?? A new Missouri law prohibiting teachers from having private online conversations with students suffered a double setback Friday. First, a judge blocked it from taking effect because of free speech concerns. Then the governor called for its repeal.
The law limiting teacher-student conversations through social networking sites such as Facebook had been scheduled to take effect Sunday. But Cole County Circuit Judge Jon Beetem issued a preliminary injunction blocking it until at least February, saying the restrictions "would have a chilling effect" on free speech rights.
A couple of hours later, Gov. Jay Nixon said he would ask lawmakers to repeal the restrictions during a previously scheduled special session that starts Sept. 6. Nixon's request goes even further than the judge's order, which was confined to private conversations on non-work-related websites. The governor also wants lawmakers to reverse new restrictions on work-related websites and abolish a requirement for schools to develop written policies by January on teacher-student communications.
Nixon, who signed the legislation last month, said Friday that the provisions about online communication are "causing substantial confusion and concern among teachers, students and families" and thus should be stricken.
"In a digital world, we must recognize that social media can be an important tool for teaching and learning," said Nixon, a Democrat.
Republican state Sen. Jane Cunningham, who sponsored the measure, said she already has been working with education groups on a potential compromise that would repeal the existing law and replace it with a less-specific requirement for local school districts to develop policies about teacher-student communications. Cunningham said it's important to make the change as soon as possible.
"There's no reason for us to punt on this thing and let it continue to simmer and draw attention from all over the world," said Cunningham, who represents a suburban St. Louis district.
The Missouri law would have barred teachers from using websites that give "exclusive access" to current students or former students who are 18 or younger. That would have meant that communication through Facebook or other social networking sites had to be done in public, rather than through private messages.
The limits on Internet communications were included in a broader education bill passed earlier this year with the overwhelming support of the Legislature and various schools groups, including the Missouri State Teachers Association, which later filed suit over the social networking provisions.
One of its main provisions, which was not challenged, requires schools to share information with other districts about teachers who have sexually abused students and allows lawsuits in cases where districts fail to disclose such information and teachers later abuse someone else. Nixon said he still supports those provisions and is not asking for them to be repealed.
A public backlash began to build against the social networking provisions over the summer, as some teachers preparing for the new school year began complaining that the law could hamper both their classroom activities and school-related conversations that occur after-hours.
"This particular issue took a national tone, and we started to hear from teachers not just in Missouri but from throughout the United States," said Todd Fuller, a spokesman for the Missouri State Teachers Association.
One third-grade teacher, for example, feared the law could prevent her class from communicating with one in Australia through a closed website. Others raised concerns about virtual classrooms in which students communicate with direct messages, Fuller said.
In its lawsuit, the teachers association said websites such as Facebook and Twitter have become a common part of modern interaction between teachers and students and argued that restricting them would violate the First Amendment of the U.S. Constitution.
The judge said the teachers' lawsuit had a good likelihood of success. His order noted that social networking sites are used extensively by teachers and that the law would have restricted online communications even between family members in which teachers are parents.
"The breadth of the prohibition is staggering," Beetem wrote in his order, which blocks the law until Feb. 20 so that a hearing on a permanent injunction can be held.
The judge's order specifically assures teachers that they cannot be disciplined for engaging in private online communications with students while the injunction is in effect ? even if it is later overturned.
The attorney general's office, which defended the law in court, declined to comment Friday.
Fuller said that if lawmakers repeal the law, then the group's lawsuit would become moot. "But until that happens we wouldn't drop the suit," he added.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Source: http://www.msnbc.msn.com/id/44290234/ns/technology_and_science-tech_and_gadgets/
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L.A. gallery showcases photos of rocker Nikki Sixx (Reuters)
LOS ANGELES (TheWrap.com) ? In March of 2009, when the Annenberg Space for Photography opened in Century City in Los Angeles, the most remarked-upon guest at the gala was David LaChapelle's date, Courtney Love.
I thought of Love during an unveiling of images late last week at the Annenberg -- all taken over the last two decades by Motley Crue bassist Nikki Sixx -- when he put up a photo of a homeless woman holding a sign reading, "I'm Not A Bad Girl, I Just Made Bad Decisions."
Anyone wondering about the wisdom of the Annenberg's decision to feature the art of Sixx was happily surprised. Not only was his camera work fascinating and its variety a bit dazzling, but the rocker's world view as he answered questions from moderator Kristine McKenna and the audience was quite compelling.
Sixx, 51, said he'd been fascinated by the medium since the late '80s, but his interest didn't truly flower until around the time he got sober in 2001, after a long series of addictions, including a near-death by overdose, chronicled in his book "The Heroin Diaries."
"I'm very passionate about what I wrap my hands around," Sixx said. "The recovery wants me to engage; the addiction made me disengage."
What recovery gives one, he added, is that "it allows your heart to soften."
He noted that the subjects of his images range all over because "my life isn't consistent. My life is chaotic. Rock 'n' roll is chaos."
Sixx -- who also has a new book and album out, both titled "This Is Gonna Hurt" -- alluded not just to his sobriety but to his struggle to show his individuality growing up, starting with a rough upbringing that included a "sorta" homeless delinquent stage.
"I was a gnarly little kid, a fighter," he told the crowd. "I try to hold on to that edge.
"If you're Bill Gates," he added, individuality "is okay -- in the beginning he was (called) a whack job."
His pictures, many of them in brooding black-and-white -- like a delicate study of a wet street in Prague at 3 a.m. -- were often grabbed on the run as he toured. He's asked for a portrait of many a prostitute in the world's capitals, but a certain gentleness emerges in the shots of the homeless -- or even of a shy hotel maid who said she was too ugly to photograph.
"I said, 'I'm gonna take a picture and show you you're beautiful.'"
The resulting image did just that.
"I'm an emotional terrortist," Sixx said. "If I see you have pain, I'm gonna pull it out of you."
Sixx's appearance was part of the Annenberg's "Iris Nights" lecture series and is linked to the gallery's "Beauty Culture" exhibit, which runs through November 27.
Source: http://us.rd.yahoo.com/dailynews/rss/tv/*http%3A//news.yahoo.com/s/nm/20110828/stage_nm/us_nikkisixx
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The Right Brunswick Bowling Balls
Often you will see that fantastic discounts on Brunswick bowling balls however are they the very best bowling balls? There's what continues to be termed: "a structural revolution" happening right here. Companies enhance on bowling balls continuously, aiming to build, and create the most effective bowling balls.
Historically, bowling balls have been created of lignum vitae, that's an astonishingly difficult wooden. While you know now, clearly, people are certainly not the Brunswick bowling balls that might qualify as being the best bowling balls.
There have been in fact bowling balls which were, at an individual time from the early twentieth century, created of rubber. They had been named the evertrue. These have been now the very best bowling balls readily available back again then. Tough rubber mineralite bowling balls truly had been the ideal bowling balls till the late twentieth century.
Polyester balls then took more than because the most beneficial bowling balls, after once again, displaying the growth remaining constructed to 1 day construct the very best bowling balls at any time. And we're receiving nearer and nearer.
The primary leading switch while in the models that created to the bowling balls we now have presently was the introduction within the perfect bowling balls nonetheless, developed of polyester. 10 ages later on, balls developed of urethane have been the most effective Brunswick bowling balls owing to their new and enhanced layout. It had been later on found out that urethane produced particularly excellent coverstock for keeping your ball.
Utilizing a technical style, the right bowling balls ended up developed by their producers. They say the "core design" will be the essential. Pc application is definitely an necessary element of developing Brunswick bowling balls to create the best. With know-how and pattern, all the community has created huge changes not excluding the quest to produce the perfect bowling balls ever before!
One can find naturally, growth specs. Most suppliers have a very objective (besides capital) to create much more standardized bowling devices, merchandise, and add-ons. The present laws need a diameter someplace among eight.500 and eight.595.
Be really mindful to not go with a ball which is as well large - girls should really go with a ball weighing about ten lb, even while males can consider 15 lb one particular. Skilled bowlers advise that folks ought to selected the balls which might be ten occasions lighter than their system body weight. So, to illustrate, if you should weigh 200 lbs, they propose which you consider a twenty lb bowling ball.
Many of these balls have 3 holes: 1 to the center finger, an individual to the index finger and a person for your thumb. It is critical that following the acquire, an authority while in the authorized bowling store drills you a hole to ensure that your fingers healthy completely within the ball you simply purchased.
Pretty much all bowling balls, don't just the most beneficial bowling balls, are requested to fulfill specified specifications and obtain approval from the ABC (American Bowling Congress) following to be examined properly by authorities.
Each of the preferred bowling balls you'll find will definitely healthy the standards for an outstanding ball. If you need to store with the very best Brunswick bowling balls, the best tough and reliable. Usually do not waste important time basically seem about on line therefore you will probably be thrilled you probably did.
Source: http://www.articlesnatch.com/Article/The-Right-Brunswick-Bowling-Balls/2899063
Sunday, August 28, 2011
Workplace Safety ? How Safe is Too Safe? | Business Tutorials ...
Safety in The Workplace
The workplace is where you probably spend most of your waking hours. Therefore it is imperative that you maintain a safe and healthy work environment. Work-related injuries can cause you or your employees physical pain, cause your business to lose profits, and cause everyday stress in your life. The truth is that it can be fun and easy to apply safe practices to any workplace. new and interactive web technologies make it fun and easy to take online safety courses. The true question is.
Click link below to read full and original article
Workplace Safety ? How Safe is Too Safe?
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Source: http://www.business4noobs.com/workplace-safety-how-safe-is-too-safe/
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Tricks You Need To Be Aware Of When It Comes To Banner ...
You could adhere to some of these very helpful tips to guarantee that you would create truckload of visitors to your website by way of your banner advertisements.
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To begin with and foremost, you require a banner of program. If you have awareness in flash, you could make one yourself. If not, then you could employ another person that could build a professional searching banner that you would show all of us. Make convinced that the phrases that is incorporated in your banner is catchy, which will make all of us interested in your site.
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2nd point is that do a small investigation. Check out to lookup for community forums, website pages, or even internet pages that are pertinent to your line of business enterprise of course. For certain you would locate tons of them. You could basically leave a comment along with your banner for the other viewers to be directed to your website.
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But make sure that the web page that you will be displaying your banner advertisements has great page rankings and a very low alexa ranking.
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By executing these two crucial items, site visitors to your website could substantially increase.
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In the new era of the time new means of on the web advertising are getting found and employed for business enterprise achievement in promoting on the internet. Every last marketer is hoping to discover out most powerful ways of on line promotion so that they can get large targeted site visitors for their on the net business.
]]>
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There are lots of ways of undertaking on the internet advertising and marketing For instance face-to-experience marketing (called chatting), banner advertisement, spend per click, Compensated electronic mail promotion, affiliate promotion, website link exchange and so forth. But conclusion to select the very best marketing procedure is pretty necessary aspect of the game.
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The importance of on the web advertisement can not be denied by anyone mainly because of its rewards. To get maximum success from your on the net advertising campaigns all basic facts to be collected previous to commence carrying out it like what is on line advertising, why to do it and how it functions for your business enterprise promotion. You will need to also know that what strategies are currently being utilized by on the net advertisers for marketing of your small business website and how to opt for the greatest on line advertisers out of the millions obtainable on-line.:)
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A stage in advance of you choose the greatest on-line advertiser or marketing company, you must make certain that by what approach they will market your website. Regardless of whether the targeted traffic is targeted or pressured? Only search engines can deliver the Healthy targeted website traffic but it requires a whole lot to sustain the great ranking on lookup engines particularly in Google lookup engine. 3rd party targeted website traffic is also valuable in some scenarios as compared to Healthy site visitors as it has a lot more sale?s conversion ratio.
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Targeted email promotion is an additional source of website traffic in which an email with a message plus your affiliate or web-site URL website link is contained and your concept and link URL is sent to the mailing checklist. In this procedure individuals click on on your message and your website link automatically open your web site, they read it and if uncovered acceptable, they purchase, use or bookmark your services. This is how you get target targeted traffic for your website from e-mail advertising and marketing. There are so a lot of e mail advertising agencies out there on world wide web that give the authentic, natural target targeted visitors to your site on compensated basis.
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PPC- Spend per click on adverts is a different way to get site visitors in which you require to spend to the advertiser per visitor they send to you.
Zach is a wonderful addition to our group and brings numerous a long time of practical experience to the group. Make sure you assist welcome him and allow him to aid you currently with this cost-free details. <a rel=?nofollow? onclick=?javascript:_gaq.push(['_trackPageview', '/outgoing/article_exit_link/4701380']);? href=?http://banner-advertising-costs28.wikispaces.com/Tricks+You+Need+To+Have+Knowledge+About+When+It+Comes+To+Banner+Advertising+Prices?>Tips You Need To Be Aware Of When It Comes To Banner Advertising Companies</a>, <a rel=?nofollow? onclick=?javascript:_gaq.push(['_trackPageview', '/outgoing/article_exit_link/4701380']);? href=?http://lenbrowers1128076.webs.com/apps/blog/show/6883966-stu
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Saturday, August 27, 2011
iPhone 5 also headed to T-Mobile USA this fall?
TiPb’s hearing that T-Mobile is well on their way to prepping their iPhone 5 roll out, likely for this October (which just so happens to coincide with the timeline we previously heard Apple was considering for launch). If Sprint iPhone 5 rumors are to be believed,...
Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/4Y0kvtsVYIo/
Demorest Law Firm Welcomes New Attorney | Animal Rescue
Royal Oak, MI (Vocus/PRWEB) April 04, 2011
Demorest Law Firm is pleased to announce that David E. Nykanen has joined the firm as a Principal. Mr. Nykanen has 15 years of practice in the Detroit area, during which he has spent his time focusing on real estate and business law.
Mr. Nykanen is one of the leading attorneys in Michigan for property tax appeals and is available to handle tax appeals for commercial properties, including commercial, retail, industrial and multi-family properties. He can also handle tax appeals for subdivisions, condominium associations and high-end residential properties.
Mr. Nykanen has outstanding credentials. He was a magna cum laude graduate of Oakland University, receiving his B.A. in 1992 and was selected as the outstanding male graduate. Nykanen then attend Wayne State University Law School, where he was Managing Editor of the Wayne Law Review. He graduated cum laude in 1995.
Mr. Nykanen has also been recognized for his accomplishments as a lawyer. He was selected as one of the Best Lawyers in America for 2011 in the area of real estate and as a Michigan Super Lawyer in 2009 and 2010.
Additionally, Mr. Nykanen has been active in the Real Property Section of the State Bar of Michigan. He is currently a member of the Council, the governing body of the Real Property Section. He is also a former Chair of the Continuing Legal Education Committee, the Homeward Bound programming committee, and the Summer Conference committee. Mr. Nykanen previously served as the Chair of the Oakland County Bar Association?s Real Estate Law Committee.
Serving as outside general counsel to small and medium-sized businesses, and helping larger companies and other law firms with specific projects, Demorest Law Firm, PLLC, provides a full range of legal services for businesses. The firm also represents individuals in certain matters and has particular expertise in the areas of business law, real estate matters, litigation, employment law, construction law, condemnation, inverse condemnation and sports law. Additionally, Demorest Law Firm, PLLC has expertise in tax, estate planning and probate matters.
Demorest Law Firm strives to understand each client?s specific business goals and objectives, allowing the firm to provide more efficient and effective legal solutions to clients. The firm knows that using the same lawyer?s services again and again is the greatest compliment a client can give a lawyer, and the Demorest Law Firm is proud to have represented many business clients for years, some for over 20 years.
# # #
Source: http://animal-rescue.social.net/2011/08/25/demorest-law-firm-welcomes-new-attorney/
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Single protein, key to Ebola virus infection, could aid in drug design
ScienceDaily (Aug. 24, 2011) ? Research published by two teams of Army scientists and collaborators has identified a cellular protein that plays a critical role in Ebola virus infection. The findings, published online in separate studies in the journal Nature, suggest a possible strategy for combating one of the world's most deadly viruses.
Ebola causes hemorrhagic fever with case fatality rates as high as 90 percent in humans. The virus is of concern both as a global public health threat and as a potential agent of biological terrorism. Currently there are no available vaccines or therapies to combat the disease. In addition, much is still unknown about the exact mechanism by which Ebola virus invades cells and causes infection.
In one Nature study, scientists from USAMRIID, Albert Einstein College of Medicine, the Whitehead Institute for Biomedical Research, and Harvard Medical School searched for proteins that Ebola virus might use to enter cells. One such cellular protein, known as Niemann-Pick C1 (NPC1), stood out: The team found that if cells don't make NPC1, they cannot be infected by Ebola virus.
According to the authors, the NPC1 protein is embedded within cell membranes, where it helps transport cholesterol within the cell. However, the absence of NPC1 due to gene mutations causes a rare degenerative disorder called Niemann-Pick disease, in which cells become clogged with cholesterol and eventually die.
To confirm the group's finding that NPC1 is crucial for Ebola virus infection, John M. Dye, Ph.D. and colleagues at USAMRIID used mice that were partially deficient in NPC1 expression, challenging the animals with lethal doses of Ebola virus. Remarkably, most of the mice survived the challenge. Other studies using cells from people with Niemann-Pick disease found that those cells also were resistant to Ebola virus infection. In addition, the researchers showed that treating cells with a compound that blocks NPC1 function inhibited infection.
In the second Nature article on this topic, another team of USAMRIID scientists, working with investigators from Brigham and Women's Hospital and Harvard Medical School, independently arrived at the same conclusion -- that Ebola virus needs NPC1 to enter the cell and cause infection.
The BWH group used a robotic method developed by Harvard's National Small Molecule Screening Laboratory to screen tens of thousands of compounds for activity against Ebola virus. They identified a novel small molecule that inhibits Ebola virus entry into cells by more than 99 percent.
Next, USAMRIID investigators Lisa Hensley, Ph.D. and Claire Marie Filone, Ph.D. verified that the newly identified inhibitor, or compound, blocked cell-to-cell transmission of Ebola virus. Using the inhibitor as a probe to investigate the pathway of infection, they found that the target of the inhibitor is NPC1 -- the same cell protein described by the other research team. The findings suggest that small molecules that target NPC1 and inhibit Ebola virus infection have the potential to be developed into antiviral drugs.
"The fact that two groups identified the same protein, using two different experimental approaches, is significant," Dr. Dye commented. "This independent corroboration greatly increases our confidence in the findings."
Dr. Hensley said both studies represent the first step in a promising line of research that could make it possible for scientists to design therapeutics that impede the ability of the Ebola virus to infect and spread.
Both projects received funding support from the Defense Threat Reduction Agency (DTRA).
The work completed at USAMRIID using authentic Ebola virus was critical for validating the role of NPC1 in Ebola virus infection. This research can only be conducted in maximum containment Biosafety Level 4, or BSL-4, laboratories, where investigators wear positive-pressure suits and breathe filtered air as they work.
USAMRIID, located at Fort Detrick, Maryland, is the only Department of Defense laboratory with BSL-4 capability. The Institute is the lead military medical research laboratory for DTRA's Joint Science and Technology Office for Chemical and Biological Defense, and plays a key role in national defense and in infectious disease research.
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Story Source:
The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by US Army Medical Research Institute of Infectious Diseases, via EurekAlert!, a service of AAAS.
Journal References:
- Jan E. Carette, Matthijs Raaben, Anthony C. Wong, Andrew S. Herbert, Gregor Obernosterer, Nirupama Mulherkar, Ana I. Kuehne, Philip J. Kranzusch, April M. Griffin, Gordon Ruthel, Paola Dal Cin, John M. Dye, Sean P. Whelan, Kartik Chandran, Thijn R. Brummelkamp. Ebola virus entry requires the cholesterol transporter Niemann?Pick C1. Nature, 2011; DOI: 10.1038/nature10348
- Marceline C?t?, John Misasi, Tao Ren, Anna Bruchez, Kyungae Lee, Claire Marie Filone, Lisa Hensley, Qi Li, Daniel Ory, Kartik Chandran, James Cunningham. Small molecule inhibitors reveal Niemann?Pick C1 is essential for Ebola virus infection. Nature, 2011; DOI: 10.1038/nature10380
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/I-jzTnBXvag/110824192329.htm
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Personal Loans for bad credit: an appropriate financial solution ...
[unable to retrieve full-text content]Bad credit personal loans are meant to assist those with severe credit defaults. The loans provide the much needed support, which then can be used to deal with the various needs and demands. These loans can be further ...
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Friday, August 26, 2011
What Is Penny Stock Investing? | Daily Rosetta - Personal Finance ...
Article by mark Crisp
The point of this article is to help you to the next level and show you what this amazing subject has to offer.
How to use money stockpiles to produce Wealth and Profit on the stockpile promote
A penny stock is clear as any stock that is trading for fewer than ten cashs. some investors put their own definition into place for penny stocks, such as any stock rated below three dolalrs.
Others deem a confirmed penny stock to be a stock merit fewer than one cash that?s trading off of a main stock swap. again, it all depends on who you ask because officially, it doesn?t concern if the stock is on a main swap because the important feature is the rate of the stock, not where it?s being traded.
If you liked the first section of this article, stay tuned because we have more to follow in the next section!
money stocks sometimes go by different names. Day traders and investors use that time interchangeably with times such as nano, micro, and small caps. money stocks come from companies with a small equal of capitalizations, which means the equal rate of their business stock
You can invest in penny stocks with a small first investment, but you typically have fewer information to go by when it comes to evaluating the business. with a better business that has stocks trading at more than a cash, you?re able to access hearsay filed with the SEC to conduct a examine before you invest.
But even while penny stocks don?t allow you that luxury, it?s a way to get in the ground level of investing with an up-and-approach business that has limitfewer probable. You may have to do more labor to do your training on penny stock companies, but it can pay off in your investments.
If you find a penny stock that you?d like to deem, you want to test to see if the business has made their fiscal hearsay untaken to the shared. Don?t just take somebody?s word for it that a certain penny stock is merit investing in.
If you find something strange, such as the auditors retreat?t licensed a business?s fiscal statements, then you should be alert about trading in that stock. Another red identify is if the auditors have affirmed that the business may not have enough money to keep working.
With penny stock investing, there are no tiniest values they have to rally for their listings, while they?re done on the OTCBB (OTC dispatch live) and the Pink Sheets.
Where does chance play a feature in penny stock investing? while the price to trade penny stocks is relatively low, the chance is a bit senior because you don?t have a way to see the chronicle of the business or the stocks and how it features into your investment plan.
When we learn, we continue on a path of growth. Therefore, learning about this subject has already helped you more than you know.
- The Things You need To Know About Penny Stock Investing
- Squawk Box Hot Penny Stock Penny Stock Investing Tips Chartpoppers
- What are the tax implications of investing in the stock market? what are the risks?
- Guidelines on Investing in Penny Stock That Matters
- Penny Stock Investing
Source: http://www.dailyrosetta.com/what-is-penny-stock-investing/33158.html
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Nail polishes for Fall 2011 - Pocket Change Shopping Blog
Do you switch out linen for cashmere or wool when fall rolls around? Do you avoid white shoes like the plague after Labor Day? Why not keep your nail polish season-appropriate too?
Refinery29?s Fall Nail-Polish Guide is a great resource for seasonal colors. Per their guide, and my own ideas, here are a couple of polishes that will help the transition from summer to autumn and winter a little softer:
Earthy greens bring the feeling of spring foliage during the barren winter months. Those splurging on a bottle of polish should look to Butter London 3 Free Nail Polish in Wallis ($14, Amazon.com), a glam olive-gold color, while those looking for a cheap fix will enjoy the more wallet-friendly Rags to Riches by Rimmel London Lasting Finish Pro ($3.99, Ulta), a mossy metallic green with silver rather than gold undertones. If you don?t want shimmer, Deborah Lippmann also offers the deep green forest-in-a-bottle Billionaire ($16, Neiman Marcus).
Burgundy is the essential deep red for the colder months. For your burgundy polish fix, try Essie nail polish in Carry On, a delicious purplish-brown with wine undertones ($8, Beauty.com). The wittily-named Stop Whining is a shimmery maroon very close to the Essie hue, from the fall nail polish line of Allure 2009 Top Innovator Sonia Kashuk ($4.99, Target).
Blue is not just for summer! Carry this Summer 2011 trend into fall and winter with deeper hues of nail polish. The subtle and sophisticated Sephora by OPI Nail Colour in My Personal Serpent looks nearly black in the shade, but in the sun transforms, chameleon-like, into a dark blue cream with gray/black undertones ($9.50, Sephora). Or try Dior Vernis in Blue Denim, a cheerful blue cream with a purple base that adds a casual touch to your look ($22, Nordstrom). Dior Vernis Blue Tie Collection in Tuxedo is a shimmery deep blue that looks as satiny as a ball gown ($21, Bloomindales).
Source: http://pocketchange.become.com/2011/08/nail-polishes-for-fall-2011.html
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Thursday, August 25, 2011
Wild world: Millions of unseen species fill Earth
WASHINGTON?? Our world is a much wilder place than it looks.
A new study estimates that Earth has almost 8.8 million species, but we've only discovered about a quarter of them. And some of yet-to-be-seen ones could be in our own backyards, scientists say.
So far, only 1.9 million species have been found. Recent discoveries have been small and weird: a psychedelic frogfish, a lizard the size of a dime and even a blind hairy mini-lobster at the bottom of the ocean.
"We are really fairly ignorant of the complexity and colorfulness of this amazing planet," said the study's co-author, Boris Worm, a biology professor at Canada's Dalhousie University. "We need to expose more people to those wonders. It really makes you feel differently about this place we inhabit."
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While some scientists and others may question why we need to know the number of species, others say it is important.
There are potential benefits from these undiscovered species, which need to be found before they disappear from the planet, said famed Harvard biologist Edward O. Wilson, who was not part of this study. Some of modern medicine comes from unusual plants and animals.
"We won't know the benefits to humanity (from these species), which potentially are enormous," the Pulitzer Prize-winning Wilson said. "If we're going to advance medical science, we need to know what's in the environment."
Biologists have long known that there's more to Earth than it seems, estimating the number of species to be somewhere between 3 million and 100 million. Figuring out how much is difficult.
Estimated number: Nearly 8.8 million
Worm and Camilo Mora of the University of Hawaii used complex mathematical models and the pace of discoveries of not only species, but of higher classifications such as family to come up with their estimate.
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Their study, published Tuesday in the online journal PLoS Biology, a publication of the Public Library of Science, estimated the number of species at nearly 8.8 million.
Of those species, 6.5 million would be on land and 2.2 million in the ocean, which is a priority for the scientists doing the work since they are part of the Census of Marine Life, an international group of scientists trying to record all the life in the ocean.
The research estimates that animals rule with 7.8 million species, followed by fungi with 611,000 and plants with just shy of 300,000 species.
While some new species like the strange mini-lobster are in exotic places such as undersea vents, "many of these species that remain to be discovered can be found literally in our own backyards," Mora said.
Number could be low
Outside scientists, such as Wilson and preeminent conservation biologist Stuart Pimm of Duke University, praised the study, although some said even the 8.8 million number may be too low.
The study said it could be off by about 1.3 million species, with the number somewhere between 7.5 million and 10.1 million. But evolutionary biologist Blair Hedges of Penn State University said he thinks the study is not good enough to be even that exact and could be wrong by millions.
Hedges knows firsthand about small species.
He found the world's smallest lizard, a half-inch long Caribbean gecko, while crawling on his hands and knees among dead leaves in the Dominican Republic in 2001. And three years ago in Barbados, he found the world's shortest snake, the 4-inch Caribbean threadsnake that lays "a single, very long egg."
The study's authors point to other species as evidence of the growing rate of discovery: the 6-inch blind, hairy lobster-type species found in 2005 by a submarine looking at hydrothermal vents near where the Pacific meets Antarctica and a brilliant-colored frogfish found by divers in Indonesia in 2008.
Of the 1.9 million species found thus far, only about 1.2 million have been listed in the fledgling online Encyclopedia of Life, a massive international effort to chronicle every species that involves biologists, including Wilson.
If the 8.8 million estimate is correct, "those are brutal numbers," said Encyclopedia of Life executive director Erick Mata. "We could spend the next 400 or 500 years trying to document the species that actually inhabit our planet."
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Source: http://www.msnbc.msn.com/id/44248318/ns/technology_and_science-science/
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Easy For Business On A Solo Female Trip at Wayfaring Travel Guide
Aug23
Situated within the really courageousness of downtown Melbourne is the Rydges Hotel. Its CBD tactfulness (Port Confection) places it closemouthed to almost every great leisure and sector direction in the municipality. Rydges Hotel Town is a premiere and grouping people hotel settled in Melbourne?s edifice region. Rydges Melbourne hotel offers the discriminating person swish and current environment, united with all the bodoni conveniences, services and facilities that are unsurprising from Melbourne?s perform 4.5 actor hotel betterment.
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Facilities: Business Center, Concierge, Elevator, 24 Hour Reception, Babysitting / Child Services, Banquet Facilities, Conference Room(s), Room Service, Restaurant, Disabled Access, Bar , Air Conditioned, Non-Smoking Rooms, Refrigerator, Satellite TV, In Room Movies, Hair Dryer, TV, Wheel Chair Access, Currency Exchange, Safe-Deposit Box, Secretarial Service, Wake-up Service, Meeting Rooms, Laundry service,? Direct dial phone.
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Mortgage refinancing rises | LoanSafe.org
Source: By Roddie Burris, The State, Columbia, S.C.) ? Mortgage rates have been hitting all-time lows in recent weeks, making it cheaper than ever to borrow money for a house.
That hasn?t sparked a run on real estate in an economy that can?t seem to find its way back to recovery. But it does have Midlands? homeowners rushing to refinance ? either to save money on their monthly payments or to shave years off their loans.
David Hyatt, senior vice president of Midland Mortgage Corp., said he has seen business triple in the past month as rates have dipped as low at 4.15 percent for a 30-year, fixed-rate mortgage and 3.6 percent for a 15-year, fixed-rate mortgage, a popular refinancing option.
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?We?re pretty busy right now,? said Hyatt. ?Many of our clients are coming in and saying they never thought they?d be refinancing again. But the rates are so low.?
Despite the ultra-low rates, the rush to refinance likely will be tempered because rates have been low for several years, said Bob Graybill, owner of Gulfstream Mortgage Corp. in Forest Acres. Rates dipped to about 4.25 percent for a 30-year mortgage two years ago, spurring many homeowners to lock in low rates then.
?At that point, you had more people out there in the market who had higher rates and were more primed to refinance,? Graybill said. ?Now, it?s probably not quite as crazy because people have lower rates in general.?
Still, Graybill said he has seen his business double in recent weeks as rates have fallen.
Homeowners should have plenty of opportunities ? through the end of next year ? to refinance or lock in a low rate on a new home. The Federal Reserve recently announced plans to hold its interest rates at practically zero through 2013 in a bid to help jump-start the stalled U.S. economy.
A homeowner who bought a house even five or six years ago likely can save money now by refinancing, industry professionals said.
?If you can cut your mortgage rate by 1.5 (percentage points by refinancing), it would probably do you good,? Hyatt said. ?If you can cut your rate by 2 (percentage points), it?s a no-brainer.?
While some have complained of tight credit, loans are available, the experts say.
Interest rates will vary for each consumer, based on an array of factors. Some lenders are willing to go even lower than the going rates if buyers are willing to ?buy down? points with upfront fees.
Credit scores also are a factor. Consumers in most cases must have a 620 credit score or better to qualify to refinance, but those with excellent credit will get the best rates. And consumers who are refinancing must have equity in the house and pay an upfront cost for the transaction, industry experts said.
The ultra-low rates have many homeowners abandoning 30-year mortgages, opting instead for a 10-year or 15-year mortgage contract.
A fixed-rate mortgage for 15 years goes for about 3.6 percent, but reports say aggressive quotes can go as low as 3.3 percent.
By going to the shorter-term mortgage at the lower rates, customers cut the remaining time on their loans, cut the interest they must pay, and if they?re lucky, end up paying roughly the same amount for their monthly note.
A homeowner who bought a home five years ago for $150,000 with a 6 percent, 30-year, fixed-rate mortgage would be making monthly payments of $900, Hyatt said. Refinancing into a 15-year loan at 3.5 percent would add about $170 to the monthly payment but would shave more than a decade of payments off the loan. That same homeowner could save $185 a month by opting for another 30-year mortgage, Hyatt said.
?It is absolutely an environment where (refinancing) makes sense,? Graybill said.
___
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I am the founder of LoanSafe.org, LoanWorkout.org and CEO of MoeSeo Inc. My work has been featured in the New York Times, LA Times, Fox Business and many other media publications. My goal is to help people with my websites and restore hope through the internet. I was born and raised in Southern California and currently reside in Temecula, California with my wife and five children.Wednesday, August 24, 2011
FDA approves Zelboraf and companion diagnostic test for late-stage ...
The U.S. Food and Drug Administration today approved Zelboraf (vemurafenib), a drug to treat patients with late-stage (metastatic) or unresectable (cannot be removed by surgery) melanoma, the most dangerous type of skin cancer.
Zelboraf is specifically indicated for the treatment of patients with melanoma whose tumors express a gene mutation called BRAF V600E. The drug has not been studied in patients whose melanoma tests negative for that mutation by an FDA approved diagnostic.
Zelboraf is being approved with a first-of-a-kind test called the cobas 4800 BRAF V600 Mutation Test, a companion diagnostic that will help determine if a patient?s melanoma cells have the BRAF V600E mutation.
The BRAF protein is normally involved in regulating cell growth, but is mutated in about half of the patients with late-stage melanomas. Zelboraf is a BRAF inhibitor that is able to block the function of the V600E-mutated BRAF protein.
?This has been an important year for patients with late-stage melanoma. Zelboraf is the second new cancer drug approved that demonstrates an improvement in overall survival,? said Richard Pazdur, M.D., director of the Office of Oncology Drug Products in the FDA?s Center for Drug Evaluation and Research. ?In March, we approved Yervoy (ipilimumab), another new treatment for late-stage melanoma that also showed patients live longer after receiving the drug.?
Zelboraf was reviewed under the FDA?s priority review program that provides for an expedited six-month review of drugs that may offer major advances in treatment or that provide a treatment when no adequate therapy exists. Zelboraf and the companion BRAF V600E test are being approved ahead of the drug?s Oct. 28, 2011 goal date and the companion diagnostics? Nov. 12, 2011 goal date.
Zelboraf?s safety and effectiveness were established in a single international trial of 675 patients with late-stage melanoma with the BRAF V600E mutation who had not received prior therapy. Patients were assigned to receive either Zelboraf or dacarbazine, another anti-cancer therapy. The trial was designed to measure overall survival (the length of time between start of treatment and death of a patient).
The median survival (the length of time a patient lives after treatment) of patients receiving Zelboraf has not been reached (77 percent still living) while the median survival for those who received dacarbazine was 8 months (64 percent still living).
?Today?s approval of Zelboraf and the cobas test is a great example of how companion diagnostics can be developed and used to ensure patients are exposed to highly effective, more personalized therapies in a safe manner,? said Alberto Gutierrez, Ph.D., director of the Office of In Vitro Diagnostic Device Evaluation and Safety in the FDA?s Center for Devices and Radiological Health.
The FDA?s approval of the cobas 4800 BRAF V600 Mutation Test was based on data from the clinical study that also evaluated the safety and effectiveness of Zelboraf. Samples of a patient?s melanoma tissue were collected to test for the mutation.
The most common side effects reported in patients receiving Zelboraf included joint pain, rash, hair loss, fatigue, nausea, and skin sensitivity when exposed to the sun. About 26 percent of patients developed a skin-related cancer called cutaneous squamous cell carcinoma, which was managed with surgery. Patients treated with Zelboraf should avoid sun exposure.
Zelboraf is being approved with a Medication Guide to inform health care professionals and patients of Zelboraf?s potential risks.
In July 2011, the FDA issued a new draft guidance to facilitate the development and review of companion diagnostics. The guidance, currently available for public comment, is intended to provide companies with guidance on the agency?s policy for reviewing a companion diagnostic and the corresponding drug therapy.
Melanoma is the leading cause of death from skin disease. The National Cancer Institute estimated that 68,130 new cases of melanoma were diagnosed in the United States during 2010; about 8,700 people died from the disease.
Zelboraf is marketed by South San Francisco based-Genentech, a member of the Roche Group. The cobas 4800 BRAF V600 Mutation Test is manufactured by Roche Molecular Systems in Pleasanton, Calif.
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